![]() ![]()
0 Comments
![]() On average it would be expected that the smoke particles around a struck match would drift away from each other, diffusing throughout the available space. As it drifts left or right, qualitatively it looks no different it is only when the gas is studied at a macroscopic scale that the effects of entropy become noticeable (see Loschmidt's paradox). Watching a single smoke particle buffeted by air, it would not be clear if a video was playing forwards or in reverse, and, in fact, it would not be possible as the laws which apply show T-symmetry. When studying at a microscopic scale, the above judgements cannot be made. Because of the second law of thermodynamics, entropy prevents macroscopic processes showing T-symmetry. When a law of physics applies equally when time is reversed, it is said to show T-symmetry in this case, entropy is what allows one to decide if the video described above is playing forwards or in reverse as intuitively we identify that only when played forwards the entropy of the scene is increasing. ![]() Surprisingly, in either case the vast majority of the laws of physics are not broken by these processes, a notable exception being the second law of thermodynamics. A video may depict a wood fire that melts a nearby ice block, played in reverse it would show that a puddle of water turned a cloud of smoke into unburnt wood and froze itself in the process. ![]() For example, it is often very easy to tell the difference between a video being played forwards or backwards. Much like temperature, despite being an abstract concept, everyone has an intuitive sense of the effects of entropy. In thermodynamic systems that are not isolated, local entropy can decrease over time, accompanied by a compensating entropy increase in the surroundings examples include objects undergoing cooling, living systems, and the formation of typical crystals. Thus, entropy measurement is a way of distinguishing the past from the future. As one goes "forward" in time, the second law of thermodynamics says, the entropy of an isolated system can increase, but not decrease. ![]() Use of the second law of thermodynamics to distinguish past from futureĮntropy is one of the few quantities in the physical sciences that require a particular direction for time, sometimes called an arrow of time. ![]() ![]() The VCA control button always displays the VCA number. Right-clicking on the button provides these features: The VCA Control button always displays the VCA number. This control only affects the VCA’s fader. The VCA name displayed is the name you entered when creating and adding the VCA.įader Automation mode button. The Solo button will provide a solo which is the pre-fader sum of all channels and buses that are controlled by this VCA. The Mute button will mute ALL channels and buses that are controlled by this VCA. Only one “Spill” ( either VCA or Mixbus ) can be active at one time. If you have a group of channels assigned to a VCA master, this is a very quick way to display those channels in the main mixer area. The “Spill” button, when activated, will hide all channels that are NOT attached to the VCA Master. To assign a track to a VCA master, click on the “ VCA” button at the bottom of the Channel or Mixbus strip, and click the boxes of the the VCA you wish to assign to control the strip.Īfter VCAs are assigned, you will notice that the “ VCA” button is replaced with indicators showing which VCAs are assigned to control this strip:Īlternately, in the editor window select the tracks, and then right-click in the “Group Bar” on the left side, and choose “Assign selected channels to VCA->” VCA Strip Operation: To create a VCA master, select Track -> Add Track,Bus or VCA -> VCA Masters: You can add VCA masters in the “Track->Add Track/Bus” dialog from the main menu. ![]() Mixbus allows a channel to be attached to “unlimited” VCA masters. In the screenshot below, 4 VCA masters are visible on the right side of the mixer: ![]() Watch this video to learn more about Mixbus’s VCA implementation: Instead, it controls the value of the mute, solo and fader of the channels that are “attached” to it. Appendix C: Videos (Training and Tutorial)Ī VCA, or VCA Master, is similar to an input strip it has a fader, mute and solo button but it does not pass audio itself. ![]()
![]() There have been a large number of minor enhancements to smooth out workflows and improve compatibility with the macOS and other applications. scf files to a project, optionally base call with phred, if needed, then Trim by Quality prior to aligning or assembling. The reads (typically Sanger sequencing reads in ABI or SCF format) should not be aligned prior to running the algorithm. When the Editor or Picture tabs are active, a new floating Graphics Palette is displayed (similar in concept to the Graphics Palette for the single sequence Map tab), allowing you to turn features on and off permitting greater control over how shared domains are displayed and outlined.īoth the Align to Reference and Assembly Project windows now let you trim reads based on quality. There is a new Features tab in the protein multiple sequence alignment window where you can view, edit, create and/or delete features in each of the aligned sequences. xdna files from Serial Cloner, which is an extended version of the old DNAStrider format.Įnhancements to Outlining Shared Domains in Aligned Sequencesįirst added in MacVector 17.5, this functionality has been significantly enhanced to expose additional Feature-related functionality in Multiple Sequence Alignment documents. spf Assembly Project files from Sequencher dna files, complete with feature colors, like this plasmid downloaded from the AddGene website The results are shown in the Map tab, and you can zoom in to see the actual sequence of the hits with the guide sequence shown in lower case and the PAM sequence in upper case You can also have MacVector automatically scan for CRISPR PAM sites whenever you open a DNA sequence file - control this using the MacVector | Preferences | Scan DNA pane. The output is a mix between the current Restriction Enzyme and Nucleic Acid Subsequence searches, so you can easily see and copy the guide sequences. While MacVector does not currently search genomes for potential off-target sites, this is still a very useful function to alert you to potential CRISPR target sites. It contains most of the current Dec 2020) characterized Cas9-like enzymes, but you can always open the file and add your own. By default, MacVector uses a file called Protospacer Adjacent Motifs.pam that is located in the / Applications/MacVector/Subsequences/ folder. menu item that will scan Nucleic Acid sequences for Protospacer Adjacent Motifs associated with the CRISPR Cas9 and related enzymes cleavage and modification functions. There is a new feature accessed by the Analyze | CRISPR PAM sites. Otherwise, MacVector 18 has the identical functionality to MacVector 18.1 but with a slightly smaller disk footprint. We recommend this for all users of Intel-base Macintosh computers and for users still unning OS X 10.11 (El Capitan). ![]() It requires a minimum of macOS 10.12 (macOS Sierra). MacVector 18.1 is a Universal Binary, meaning that it runs natively on both Intal and Apple Silicon ("M1") Macintosh computers. Finally, there are major enhancements to the protein multiple sequence alignment visualization of domains and the usual macOS compatibility enhancements. There is a new CRISPR PAM sequence searching function and a Trim by Quality option for Sanger sequence files. MacVector 18 adds a number of new functions, including the ability to read a several requested file formats such as Sequencher assembly project files along with Serial Cloner and SnapGene sequence files. Sequence Analysis Tools for Molecular Biologists ![]() ![]() ![]() We all know exercise is good for physical health, but its positive impact on your mood is sometimes overlooked. If you need a hand with finding your way, try our Journey Planner. Travelling by bike gives you far more freedom and opportunity to stop and take photos, turn and look back, or even disappear up an interesting side street. You might find a new beauty spot, or perhaps even a shortcut. By cycling to work you give yourself the opportunity to take a different route and get to know your local area better. If you take public transport you might not have a choice, and if you drive it’s probably habitual, but chances are you take the same journey day after day. By cycling, you are helping to reduce the harmful and deadly emissions, effectively saving lives and making the world a healthier place to live. At present, every year in the UK, outdoor pollution is linked to up to 36,000 deaths. ![]() Getting out of the car and cycling contributes to cleaner, healthier air. When you add the CO2 emissions from the average European diet, which is around 16g per kilometre cycled, the total CO2 emissions per kilometre of riding your bike is about 21g – more than 10 times less than a car. But if you want to reduce your emissions even further, try a bicycle.Ĭycle production does have an impact, and while they are not fuel-powered, they are food-powered and producing food also creates CO2 emissions.īut the good news is that production of a bicycle sets you back only 5g per kilometre driven. Taking the bus will cut your emissions by more than half. Reduce your carbon footprintĬonsidering the average road use of European car drivers, different fuel types, average occupation, and adding emissions from production, driving a car emits about 271g CO2 per passenger-kilometre. If you need more help we’ve got 10 tips for cycling weight loss. It’s a low-impact, adaptable exercise that can burn calories at a rate of 400-750 calories per hour, depending on the weight of the rider, speed and type of cycling you’re doing. Trim up and lose weightĬycling to work can be a great way to lose weight, whether you’re just starting out or are looking to use your cycling as a way to trim up and shift a few pounds. Local businesses and communities are sometimes concerned about the economic impact of new schemes that prioritise walking and cycling over motor vehicles, however they soon warm to the idea once those schemes are in - when they see that people cycling are at least as likely to buy products and services than people in cars.Ĭycling UK’s briefing on the economic benefits of cycling has more details. Cyclists are more likely to stop and shop, benefiting local retailers. It’s good for the economyĬyclists are better for the local and national economy than motorists. They are a quick, reliable and cheap way to get around, and if you're based in Manchester, Sheffield, Leicester or Luton & Dunstable, you could try one for free through our loan scheme Making cycling e-asier. Yes, you will get fitter riding an e-bike, too. It can offer a bit of extra assistance in those early mornings, and it could be the way forward if you live somewhere hilly. If you don’t currently exercise regularly, the improvements will be even more dramatic and the benefits greater, and cycling is a great low-impact, low-to-moderate intensity way to get more active. It should be no surprise that cycling will improve your fitness. Instead of having your face stuck against other people's armpits on heaving public transport, you could be enjoying the fresh air and scenery around you. Unless you are a fan of being stuck in traffic jams, cycling is simply a much more fun way to get to work. Swap to cycling and you’ll save money every time you commute.īut just how much can you save by cycling? Cycling UK's Christina Bengston crunched the numbers. While there may be some expenses involved in cycling to work, the cost of maintaining a bike is far lower than the equivalent costs of running a car. ![]() Here are 21 reasons why you’ll never look back. Whatever you do, however far your ride, have fun. A hundred years on, this advice is more important than ever as cycling is a great transport solution that enables you to save money and get healthy at the same time.Īll you need to give it a go is a bike and the desire to ride. Since 1923, thousands of riders have celebrated everyday cycling and used Bike Week as a reason to enjoy an extra ride or try cycling to work for the first time. ![]() ![]()
![]()
![]() People try to get around this by breaking their email addresses up into chunks, like this: matt macinstruct. Evil spam-bots scour websites for email addresses – if they find yours, they’ll grab it and never let go.
![]() ![]() Savings due to deduplication can be inherited when using NetApp SnapMirror ® replication technology or Flash Cache ™ intelligent cachingĭeduplication is useful regardless of workload type.Integrated with other NetApp storage efficiency technologies. ![]()
![]() ![]() There should be no gray areas that might mislead the user. Each has a positive and negative side, and we believe transparency is of the utmost importance when tinkering with another user's machine. ![]() Advantages and disadvantages of OpenCore Legacy Patcherįor OpenCore Legacy Patcher, we recommend that users review the table below to understand the advantages and disadvantages compared to other patches. Potential boot issues with built-in USB 1.1 ports (recommend using a USB 2.0 hub or dedicated USB PCIe controller) - Potential boot issues with stock Bluetooth card, recommend removing to avoid kernel panicsĮverything is supported as long as GPU is Metal capableĦ. See here for more information: iMac late 2009 to mid-2011 Graphics Card Upgrade Guide For iMac10, 1 through iMac12, x, we highly recommend users upgrade the GPU to a Metal supported model.GPU is socketed, recommend upgrading to Metal GPU - GPU Acceleration in Public Beta, see current issues # 108 Requires an SSE4.1 CPU Upgrade - GPU Acceleration in Public Beta, see current issues # 108 - Stock Bluetooth 2.0 card non-functional GPU Acceleration in Public Beta, see current issues # 108 GPU Acceleration in Public Beta, see current issues # 108 - Trackpad is recognized as mouse No GPU Acceleration in Mavericks and newer - No Keyboard and Trackpad - No USB The following table lists all features currently supported and not supported by the patch: To check your hardware model, run the following command on the appropriate machine on your terminal: system_profiler SPHardwareDataType | grep 'Model Identifier' Copy the code Supported Mac modelsĪny hardware that supports SSE4.1 CPUS and 64-bit firmware can run on this patch. The goal of this article is to install macOS Big Sur and macOS Monterey on the following unsupported Mac models. Possible support for versions 10.4 and later (in a potentially corrupt state). Manual installation Python 3.9 or later10.7+ is supported and you only need to run the repO mand.Īn operating system that can be patched to run with OpenCore Refers to an operating system that supports OpenCore- patcher. ![]() Supported macOSįor operating system support, the following are available: Support the entry Patch warning: The Boot Camp function will be limited, the installation based on the traditional MBR will not be shown in OpenCore, and due to CPU limitations, only certain models support UEFI Windows 10, see Installing UEFI Windows 10 4. The OpenCore Legacy Patcher helps automate the process and makes running OpenCore much easier. While OpenCore is familiar to many PC users in the Hackintosh community, it has been designed to be Mac and PC neutral, ensuring it can be easily used by both platforms. Recovery OS, secure mode, and single user mode boot.System Integrity Protection (SIP), FileVault 2.This includes many of the desired features of other patches, such as: This means we can get a near-native experience on many unsupported Macs with Metal Gpus. This is a sophisticated boot loader for injecting and patching data in memory, not on disk. ![]()
|
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |